Published: Mar 12, 2019
 
 
     
 
ergotism migraine ventricular fibrillation
 
     
 
   
 
 
 
 
 
 
 
 
 
 
 

 

 
   
 
 
 
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    Home / Archives / Vol. 12 No.1 (2016): JAN - JUN / Case Report  
 
   
 

Case report: Ventricular fibrillation in patient who received ergotamine

   
 
   
   
     
 
อุกฤษฎ์ อุเทนสุต
Department of Medicine, Wetchakarunrasm Hospital, Medical Service Department, Bangkok

Abstract

Patients who received ergotamine overdose or who had a drug that can cause drug-interaction with ergotamine may have ergotism. Ergotism is a serious complication that has many effects on blood vessels especially peripheral artery. This condition may presents in various types of symptom and sign including limb ischemia, cerebral ischemia and coronary ischemia etc. This case is 18 year old male with a history of taking ergotamine for 7 tabs in 24 hours. He presented to an emergency room with sudden unconsciousness and cardiac arrest, his EKG showed ventricular fibrillation. He died after 90 minutes of cardiopulmonary resuscitation.


 There are 2 cases report of ergotamine overdose which related to coronary ischemia cases, ventricular fibrillation and myocardial infarction but none of them are dead. This case is the first case report of a dead patient from ergotamine related ventricular fibrillation. However the autopsy was not done to confirm the definite diagnosis in this patient.


Keywords: ergotism, migraine, ventricular fibrillation

 
     
     
 
    How to Cite  
     
  อุเทนสุต อ. (2016). Case report: Ventricular fibrillation in patient who received ergotamine. Journal of Charoenkrung Pracharak Hospital12(1), 52–61. Retrieved from https://he02.tci-thaijo.org/index.php/JCP/article/view/177733  
     

 
 
     
     
 
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  Vol. 12 No.1 (2016): JAN - JUN  

 
 
     
     
 
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References

1. Sanders-Bush E, Mayer S. 5-Hydroxytryptamine (Serotonin): receptor agonist and antagonist. In: Goodman Gilman A, Hardman JG, Limbird LE, editors. The Pharmacological basis of therapeutics. 10th ed. Buenos Aires: McGraw-Hill 2001; p.283-4.
2. Zavaleta EG, Fernandez BB, Grove MK, Kaye MD. St. Anthony’s fire (ergotamine induced leg ischemia)
a case report and review of the literature. Angiology 2001; 52: 349-56.
3. Eadie MJ. Clinically significant drug interactions with agents specific for migraine attacks. CNS Drugs. 2001; 15: 105-18.
4. Dresser GK, Spence JD, Bailey DG. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin Pharmacokinet 2000; 38: 41-57.
5. Meyler WJ. Side effect of ergotamine. Cephalagia 1996; 16: 5-10.
6. Reynolds J. Martindale: The extra pharmacopoeia. London: Royal Pharmaceutical Society 1996; p.481-3.
7. Kumar GN, Rodrigues AD, Buko AM, Denisien JF. Cytochrome P-450 mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther 1996; 227: 423-31.
8. Baldwin ZK, Ceraldi CC. Ergotism associated with HIV antiviral protease inhibitor therapy. J Vasc Surg
2003; 37: 676-8.
9. Velez Roa S, Preumont N, Mols P, Stoupel E, Renard M. Ventricular fibrillation secondary to ergotamine in a healthy young woman. Acta Cardiol 1999; 54: 283-6.
10. Liaudet L, Buclin T, Jaccard C, Eckert P. Drug points: Severe ergotism associated with interaction between ritonavir and ergotamine. BMJ 1999; 318 :771.
11. Yasue, Hirofumi, Takizawa, Akinori, Nagao, Masao. Acute myocardial infarction induced by ergotamine tartrate: possible role of coronary arterial spasm. Angiology 1981; 32: 414.
12. Roithinger FX, Punzengruber C, Gremmel F, Hinterreiter M, Holzner F, Pachinger O. Myocardial infarction after chronic ergotamine abuse. Eur Heart J 1993; 14: 1579-81.
13. BSAMA5 Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften. (Schwabe & Co., Steinentorstr. 13, CH-4010 Basel, Switzerland) V.1-1944: 2, 1, 1946/1947.
14. RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (NewYork, NY) V.1-3, 1964-72. Discontinued. V.2; 284,1970.
15. Pardo Rey C, Yebra M, Borrallo M, Vega A, Ramos A, Montero MC. Irreversible coma, ergotamine, and ritonavir. Clin Infect Dis 2003; 37: 72-3.
16. Vila A, Mykietiuk A, Bonvehi P, Temporiti E, Uruena A, Herrera F. Clinical ergotism induced by ritonavir. Scand J Infect Dis 2001; 33: 788-9.
17. Mortier E, Pouchot J, Vinceneux P, Lalande M. Ergotism related to interaction between nelfinavir and ergotamine. Am J Med 2001; 110: 594.
18. Blanche P, Rigolet A, Gombert B, Ginsburg C, Salmon D, Sicard D. Ergotism related to a single dose of ergotamine tartrate in an AIDS patient treated with ritonavir. Postgrad Med J 1999; 75: 546-7.
19. Rosenthal E, Sala F, Chichmanian RM, Batt M, Cassuto JP. Ergotism related to concurrent administration of ergotamine tartrate and indinavir. JAMA 1999; 281: 987.
20. Montero A, Giovannoni AG, Tvrde PL. Leg ischemia in a patient receiving ritonavir and ergotamine [letter]. Ann Intern Med 1999; 130: 329-30.